In the News : Wine and Alzheimer's Disease
words to know:
amyloid peptide - proteins that bind together in the brains of Alzheimer's patients and causes the brain cells to die
proteasome - a naturally-occurring "protein eating" complex
resveratrol - an antioxidant found in grapes, berries and peanuts
The effects of red wine on Alzheimer's disease has been in the news a lot recently. And while it is true that the moderate consumption(*) of red wine is a beneficial part of your overall diet, drinking red wine will NOT keep you from getting Alzheimer's. Here are the facts.
Alzheimer's disease occurs when proteins known as amyloid peptides begin to bind together in the brain. These "clumps" of amyloid peptides and called plaques and they lodge themselves between brain cells and cause them to die. It is difficult to get the amyloid peptides to form plaques in the lab, so researchers treated the peptides, themselves, to a series of antioxidants to determine their relative effectiveness. Resveratrol was the only antioxidant that was very active in reducing the number of amyloid peptides in the cells.
The mechanism by which resveratrol works involves the bodies natural production of proteasomes. In a way not completely understood, resveratrol stimulates proteasome production and it is these molecules which effectively eliminate the amyloid peptides.
But it seems that the benefits of resveratrol may be two-fold. In a separate study, mice with an Alzheimer's like disease were divided into three groups. One group was given a water and cabernet sauvignon mixture, one group was given a water and ethanol (the "inebriation" alcohol) mixture, and the control group was simply given water for seven months. After the animals had been alcohol-free for three days, the mice were put through a series of memory testing mazes. The wine consuming group performed significantly better than the other two.
So it appears that resveratrol may not only rid the brain of the toxic amyloid peptides but may also reduce the memory loss effects of the disease itself. So if resveratrol is so good and if it is found in wine, why won't drinking wine keep you from getting Alzheimer's? The reason is you simply cannot drink enough wine to get the levels of resveratrol high enough to be effective.
But the good news is that researchers have already discovered more potent versions of resveratrol that might potentially be developed into an Alheimer's treatment and preventative. Professor Peter Davies of the Albert Einstein College of Medicine says, "This is potentially a protective compound. A compound that we could give you at age 40 or 50, whatever age you'd like to start, to protect against the development of Alzheimer's disease."
Alzheimer's research is not the only beneficiary of this amazing compound, resveratrol. A recent study by the Harvard Medical School and the National Institute of Aging has shown that heavy doses of this red wine extract lowers the rates of several obesity-related diseases in mice, including diabetes and liver problems. It seems that resveratrol can give mice, at least, the good effects of counting calories without actually doing it.
Can drinking red wine keep you from getting Alheimer's or diabetes? Not unless you are prepared to consume about 100 gallons a day! S0 even though that glass of wine may not be a magic bullet, wine drinkers take heart. That beverage you love so much, may help cure some of the most dreaded diseases facing millions of Americans.
(*)a single five ounce glass of wine for women, and two five ounce glasses for men





Recent Comments